南京鼓楼医院,又名南京大学医学院附属鼓楼医院,坐落于钟灵毓秀、虎踞龙蟠的古都——南京,前身是1892年由美国基督会资助的加拿大籍传教士威廉·爱德华·麦克林医学博士(William E. Macklin,中文译音马林”)创建的一所“基督医院”,目前为集医教研为一体的大型综合性三级甲等医院,也是全国成立较早的西医院。
鼓楼医院大力推动各公共研究平台的建设,其中临床干细胞研究室被国家卫计委批准成为全国30家三甲医院临床干细胞基地。
鼓楼医院一直以来都很重视于开展干细胞研究,在2007年,南京鼓楼医院孙凌云教授率领课题组,采用异体骨髓间质干细胞移植治疗系统性红斑狼疮,获得突破性进展———两位重症患者在接受异体骨髓间质干细胞移植治疗后,病情迅速得到控制,各项指标大有好转,服药量大幅减少;在2014年,鼓楼医院胡娅莉教授的科研团队,利用再生胶原材料复合干细胞修复子宫内膜瘢痕化导致的不育取得重大成果,多位患者相继怀孕并顺利生下健康宝宝。
鼓楼医院参与的临床干细胞研究项目如下(来源于clinicaltrials.gov)
Study Title | Conditions | Interventions |
Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS) | 干燥综合症|间充质干细胞 | 生物:异体间充质干细胞(AlloMSC) |
Biological: Allogeneic Mesenchymal Stem Cells (AlloMSC) | 系统性硬化|间充质干细胞 | 生物:异体间充质干细胞(AlloMSC) |
Allogeneic Umbilical Cord Mesenchymal Stem Cell Transplantation for Type 1 Diabetes With Diabetic Ketoacidosis | 酮症酸中毒、糖尿病 | 程序:脐带间充质干细胞 |
Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells | 不孕|子宫内粘连|子宫内膜发育不良 | 程序:自体骨髓干细胞 |
Treatment of Infertility by Collagen Scaffold Loaded With Umbilical Cord Blood-derived Mesenchyma Stem Cells | 不孕|子宫内粘连|子宫内膜发育不良 | 程序:脐带血来源的间充质干细胞 |
Efficacy and Safety Study of Autologous Hematopoietic Stem Cell Transplantation to Treat New Onset Type 1 Diabetes | 1型糖尿病 | 过程:免疫抑制和干细胞移植 |
Umbilical Cord Derived Mesenchymal Stem Cells Transplantation for Active and Refractory Systemic Lupus Erythematosus | 系统性红斑狼疮 | 生物:人类脐带移植用于系统性红斑狼疮SLE |
Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery | 直肠癌|勃起功能障碍 | 手术:腹腔镜手术|装置:NeuroRegen手术移植|生物学:NeuroRegen支架/ BMMCs移植|生物学:NeuroRegen支架/ HUC-MSC移植 |
Human Umbilical Cord-derived Mesenchymal Stem Cells With Injectable Collagen Scaffold Transplantation for Chronic Ischemic Cardiomyopathy | 慢性缺血性心肌病 | 生物学:hUC-MSCs +可注射的胶原支架+ 冠状动脉旁路移植术CABG |生物学:hUC-MSCs + CABG |程序:CABG |
Injectable Collagen Scaffold™ Combined With HUC-MSCs for the Improvement of Erectile Function in Men With Diabetes | 勃起功能障碍|1型糖尿病|2型糖尿病 | 生物学:HUC-MSCs |生物学:注射胶原支架+ HUC-MSC |
Collagen Membrane Combined With HUC-MSCs Transplantation in Patients With Nasal Septum Perforation | 慢性鼻中隔穿孔 | 生物:胶原膜+ HUC-MSC |
Injectable Collagen Scaffold™ Combined With HUC-MSCs Transplantation for Patients With Decompensated Cirrhosis | 代偿失调性肝硬化 | 生物:常规治疗|生物学:注射胶原支架+ HUC-MSC |
Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF | 卵巢功能早衰 | 生物学:HUC-MSCs移植|生物学:具有可注射胶原支架移植的HUC-MSC |
Collagen Scaffolds Loaded With HUCMSCs for the Improvement of Erectile Function in Men With Diabetes | 勃起功能障碍| 1型糖尿病| 2型糖尿病 | 生物:HUCMSC注射|生物:胶原支架/ HUCMSC注射液 |
Mesenchymal Stem Cells Transplantation for Refractory Systemic Lupus Erythematosus (SLE) | 难治性系统性狼疮红斑狼疮 | 生物学:异体MSC(AlloMSC) |
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Hereditary Ataxia | 遗传性共济失调 | 生物:人脐带间充质干细胞 |
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica | 进行性多发性硬化症| 视神经脊髓炎 | 生物:人脐带间充质干细胞 |
Low Dose Decitabine + Modified BUCY Conditioning Regimen for High Risk Acute Myeloid Leukemia Undergoing Allo-HSCT | 急性髓系白血病|同种异体造血干细胞移植 | 药物:地西他滨加修饰的环磷酰胺 |药物:修饰的环磷酰胺 |
Effects of ADSC Therapy in Women With POF | 卵巢功能早衰 | 程序:自体脂肪移植 |
Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major | 重型β地中海贫血 | 药物:巴利昔单抗,|药物:环孢素A |药物:甲氨蝶呤|药物:霉酚酸酯 |